here are a few random ones I thought of

Hank Jennings-Christian Slater, Jerry Horne-Martin Short, Ed Hurley-Bruce Campbell, Gorden Cole-Jeff Goldblum, Windom Earle-Bob Hoskins, Harold Smith-Crispin Glover, and Abe Vigoda as the Mayor.

I know, I know! Thanks, Jamie!!!

 You stole my thunder!  That's exactly the director I was going to suggest!

 In the trailer...

From the producers of Waterworld and The Adventures of Pluto Nash....

comes a scintillating mystery directed by award winner Uwe Boll...

starring future Academy Award nominee method actress Miley Cyrus and Mulholland Drive's headline actor Billy Ray Cyrus...

in this year's acclaimed remake reboot retcon...

*with Shia LaBeouf in a special guest starring role

"Harry, I'm going to let you in on a little secret. Every day, once a day, give yourself a present. Don't plan it, don't wait for it, just let it happen. Could be a new shirt at the men's store, a catnap in your office chair, or two cups of good, hot, black coffee. Like this."  -Dale Cooper

"Donna Hayward - Thora Birch"

Yes! Definitely.

Sheriff Truman-- Tommy Lee Jones. Play up the "Small town sheriff" angle and make him a southern gentleman...

As a matter of fact, maybe we relocate Twin Peaks altogether. If we're remaking/reimagining it, set it in an isolated outpost of the Southwest. The forests, rivers, and waterfalls of the Pacific Northwest give way to the mesas, prairies, and desert wastelands of the Four Corner states and western Texas.

Dale Cooper-- Matthew Broderick. He's got the same youthful exuberance that Kyle MacLachlan brought to the role, with the added benefit of age. The perfect role for the world's oldest seventeen year old.

Ben Horne-- I'm tempted to say Michael Douglas. After all, he did give us Gordon Gecko, the quintessential evil businessman. However, I'm afraid that the comparison would be too obvious (and apt). Kevin Spacey, as someone posted above, is a wonderful suggestion. He could bring the right amount of ruthless evil and startling vulnerability to the role. However, I think another great choice would be James Woods, who I think could look positively cutthroat in a tight suit and a pair of tortoise shell glasses. Ultimate badass factor: Burt Reynolds, channeling his performance in Boogie Nights.

Leland Palmer-- Tim Robbins comes to mind. After his turns in Mystic River and War of the Worlds, he seems perfectly suited to play a horrendously scarred individual. Dustin Hoffman would be interesting to watch, as well-- as of late we're used to seeing him in light comedy, and as Leland starts off borderlining on wacky, it'd seem to fit to newcomers, and take them wholly aback at the revelation of his culpability in Laura's death. My only concern would be that, outside of a big city, Hoffman's being Jewish would make him stick out like a sore thumb; then again, Leland being one of the only Jews in a small southern hick town, and no one seeming to care, could potentially add to the quirky surrealism of the show.

BOB-- Rutger Hauer. Admit it-- this is the best casting idea you've ever read.

Leo-- John Goodman. I never bought Leo as a truck driver. Sorry, Eric da Re. He was too young, too buff, and too... metrosexual, for lack of a better word. And for me, I just couldn't accept it as a facet of the show's strangeness. It just seemed an out of place casting decision. I always envisioned Leo as being somewhat older, and much more grizzled. In this incarnation, he is your stereotypical dangerous, ignorant hick. Give him a massive beer gut, a Grizzly Adams beard, and a mesh-backed cap perpetually attached to his head. Keep the pony tail, though. Failing Goodman, Billy Bob Thorton, although he'd have to pack on the pounds.

Sarah Palmer-- Diane Keaton. Man, that would kick so much ass.

That's all I can think of for now. More later. 

"Harry, I'm going to let you in on a little secret. Every day, once a day, give yourself a present. Don't plan it, don't wait for it, just let it happen. Could be a new shirt at the men's store, a catnap in your office chair, or two cups of good, hot, black coffee. Like this."  -Dale Cooper

"Harry, I'm going to let you in on a little secret. Every day, once a day, give yourself a present. Don't plan it, don't wait for it, just let it happen. Could be a new shirt at the men's store, a catnap in your office chair, or two cups of good, hot, black coffee. Like this."  -Dale Cooper

Agent Cooper -Topher Grace--just look at him, he could easily pull of the role

NBA star Dwight Howard as the Giant. 

Here is my list...

 Laura Palmer/Maddy Ferguson - Ali Larter

Donna Hayward - Camilla Belle OR Carey Mulligan

Audrey Horne - Ashley Greene

Shelley Johnson - Amanda Seyfried OR Mischa Barton OR Amber Tamblyn

Annie Blackburn - Jaime King or Siena Miller

Norma Jennings - Jennie Garth OR Julie Bowen OR Maria Bello

Josie Packard - Gong Li

Lana Budding Milford - Alicia Witt OR Isla Fischer (it would be fun to see Alicia Witt back in TP as a grown up)

Evelyn Marsh - Nicolette Sheridan OR Samantha Mathis

Betty Briggs - Rebecca De Mornay OR Laura Dern

Sarah Palmer - Joan Allen OR Melissa Leo OR Allison Janney

Eileen Hayward - Julia Ormond (saw a picture of her and she looks so much like original Eileen - to me, anyway)

Sylvia Horne - Carrie-Anne Moss OR Juliette Binoche

Catherine Martell - Laura Linney OR Julianne Moore OR Marg Helgenberger

Lucy Moran - Judy Greer

Nadine Hurley - Helene Joy (of Durham County)

Ronette Pulaski - Cassie Steele (of Degrassi - they look alike, I think)

Blackie O'Reilly - Rosie Perez

Nancy - Shannon Doherty

Leland Palmer - Willem Dafoe

Ben Horne - Greg Kinnear

Sheriff Truman - Hugh Jackman OR Patrick Dempsey

Deputy Hawk - Lou Diamond Phillips

Deputy Andy Brennen - Dietrich Badar (from the Beverly Hillbillies Movie) OR Bill Fagerbakke (Dauber on Coach)

Jack Justice Wheeler - James Marsden

James Hurley - Josh Hartnett

Bobby Briggs - Paul Wesley

Hank Jennings - Edward Burns

Leo Johnson - Orlando Bloom or Balthazar Getty

Jerry Horne - Christian Slater

Albert Rosenfield - Kevin Spacey

Big Ed Hurley - Gary Sinise

Agent Cooper - Tobey Maguire

Gordon Cole - David Morse

Richard Tremayne - Hugh Grant

Doctor Hayward - Sam Neil

Doctor Jacoby - Hugh Laurie

The Log Lady - Molly Shannon

Pete Martell - Ed Harris

Major Garland Briggs - Stanley Tucci

Jacques Renault - John Goodman

Jean Renault - Chris Cooper

Bernie Renault - Chris Owen 

Windom Earle - Tom Selleck

Dennis/Denise Bryson - William Baldwin

Danny Devito- MFAP

It just hit me:

 BRANDON ROUTH AS COOPER.